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Cibenzoline 琥珀酸盐，10MG，C1618-10MG，Sigma

销售价： ¥ 1911.14 / 件

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订货号： 0BR7102

品牌型号： Sigma C1618-10MG

货期：询货期

最小订货量： 1件

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产品介绍 Product Description

General description

Cibenzoline also called (±)-2-(2,2-diphenylcyclopropyl)-2-imidazoline succinate, is generally used in stereo combination of R(+) and S(−) forms. It also exhibits anticholinergic activity.. Cibenzoline is known to improve left ventricular diastolic dysfunction by reducing left ventricular pressure gradient.

Biochem/physiol Actions

Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.
Cibenzoline succinate inhibits ATP-sensitive K⁺ channels; class IA antiarrhythmic.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

技术参数 Specifications

Quality Segment	100
assay	≥98% (HPLC)
form	solid
storage condition	desiccated
color	white to brown
solubility	H₂O: ≥5 mg/mL
storage temp.	2-8°C
SMILES string	OC(=O)CCC(O)=O.C1CN=C(N1)C2CC2(c3ccccc3)c4ccccc4
InChI	1S/C18H18N2.C4H6O4/c1-3-7-14(8-4-1)18(15-9-5-2-6-10-15)13-16(18)17-19-11-12-20-17;5-3(6)1-2-4(7)8/h1-10,16H,11-13H2,(H,19,20);1-2H2,(H,5,6)(H,7,8)
InChI key	XFUIOIWYMHEPIE-UHFFFAOYSA-N

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