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Biochem/physiol Actions
Acriflavine is an antimicrobial drug used to treat against sleeping sickness, urinary tract infections, and gonorrhea. Acriflavine is a potent inhibitor of SARS-CoV-2 papain-5 like protease (PLpro), which potently inhibits viral replication in vivo in mice and ex vivo in human airway epithelia. It is a mixture of trypaflavines (3,6-diamino-10-methylacridinium chloride and 3,6-diamino-3-methylacridinium chloride) and proflavine (3,6-diaminoacridine). Apparently commercial acriflavine mixtures contain the combination of differently methylated proflavines to optimally block the PLpro active site. Also, it potently inhibits replication of other betacoronaviruses.
Antimicrobial; potent inhibitor of SARS-CoV-2 papain-5 like protease (PLpro) and inhibits virus replication
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | powder |
| color | red to brown |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | NC1=CC2=C(C=C1)C=C3C=CC(N)=CC3=N2.NC4=CC5=C(C=C4)C=C6C=CC(NC)=CC6=N5.NC7=CC8=C(C=C7)C=C9C=CC(N)=CC9=[N+]8C.[Cl-].Cl.Cl |
| InChI key | CNKPVFNEZPNSQB-UHFFFAOYSA-N |
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¥ 2019.57
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¥ 1866.29
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¥ 4173.75
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¥ 3152.47
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¥ 1156.91
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¥ 1783.21
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¥ 787.34
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¥ 4614.63
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¥ 18741.69
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