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XMD8-92，5MG，SML1382-5MG，Sigma

销售价： ¥ 1463.25 / 件

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订货号： 0BR0557

品牌型号： Sigma SML1382-5MG

货期：询货期

最小订货量： 1件

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产品介绍 Product Description

Application

XMD8-92 has been used as a specific extracellular signal regulated kinase 5 (ERK5) inhibitor in human umbilical vein endothelial cells (HUVECs) culture.

Biochem/physiol Actions

XMD8-92 is a potent and selective inhibitor of BMK1/ERK5/MAPK7 and DCAMKL1 (DCLK1) kinases, implicated in tumorigenesis.
XMD8-92 is a potent and selective inhibitor of BMK1/ERK5/MAPK7 and DCAMKL1 (DCLK1), kinases implicated in tumorigenesis. XMD8-92 has a Kd of 80 nM for ERK5 and a Kd of 97 nM for DCAMKL1. The next closest targets are DCAMKL2 (190 nM), TNK1 (890 nM), and PLK4 (600 nM). Through inhibition of BMK1 activity, XMD8-92 blocked tumor cell proliferation in vitro in a wide variety of cancer cell lines and significantly inhibited tumor growth in vivo by 95% in mouse studies. XMD8-92 inhibited AsPC-1 human pancreatic cancer cell proliferation and pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.

Other Notes

XMD8-92 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the XMD8-92 probe summary on the Chemical Probes Portal website.

技术参数 Specifications

Quality Segment	100
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	DMSO: 25 mg/mL, clear
web metadata keyword.default	XMD8-92 1234480-50-2 procurement,XMD8-92 500mg vial,XMD8-92 DCLK1 kinase inhibitor,XMD8-92 ERK5 inhibitor for endothelial cell research,XMD8-92 ERK5 inhibitor,XMD8-92 MAPK7 inhibitor for cell signaling,XMD8-92 bioactive small molecule for research,XMD8-92 chemical probe for HUVEC culture,XMD8-92 chemical probe for cancer studies,XMD8-92 for tumorigenesis research,XMD8-92 high purity research grade,XMD8-92 inhibitor for pharmacological studies,XMD8-92 lab-grade extracellular signal regulated kinase inhibitor,XMD8-92 selective BMK1 inhibitor
storage temp.	2-8°C
SMILES string	OC(CC1)CCN1C2=CC=C(NC3=NC(N(C)C(C=CC=C4)=C4C(N5C)=O)=C5C=N3)C(OCC)=C2
InChI	1S/C26H30N6O3/c1-4-35-23-15-17(32-13-11-18(33)12-14-32)9-10-20(23)28-26-27-16-22-24(29-26)30(2)21-8-6-5-7-19(21)25(34)31(22)3/h5-10,15-16,18,33H,4,11-14H2,1-3H3,(H,27,28,29)
InChI key	QAPAJIZPZGWAND-UHFFFAOYSA-N

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