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TBPB，5MG，SML0453-5MG，Sigma

销售价： ¥ 1014.76 / 件

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订货号： 0BR0064

品牌型号： Sigma SML0453-5MG

货期：询货期

最小订货量： 1件

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商品介绍
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产品介绍 Product Description

Biochem/physiol Actions

TBPB is a highly selective Muscarinic M1 receptor allosteric agonist.
TBPB is a highly selective Muscarinic M1 receptor allosteric agonist. It activates M1 through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its selectivity. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including hippocampus, cortex, and striatum. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimer′s. M1 agonists are being studied as potential therapeutic agents to treat Alzheimer′s disease and the cognitive and negative symptoms of schizophrenia.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

技术参数 Specifications

Quality Segment	100
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	DMSO: 5 mg/mL (clear solution; warmed)
storage temp.	2-8°C
SMILES string	Cc1ccccc1CN2CCC(CC2)N3CCC(CC3)N4C(=O)Nc5ccccc45
InChI	1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30)
InChI key	CWPKTBMRVATCBL-UHFFFAOYSA-N

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