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Biochem/physiol Actions
JX06 is a potent, PDK1-selective, covalent pyruvate dehydrogenase (PDH) kinase (PDHK, PDK) inhibitor (PDK1/2/3 IC50 = 49/101/313 nM; PDK4 IC50 >10 µM, IC50 >10 µM against >300 other kinases). JX06 inhibits cellular PDK substrate PDHA1 Ser293/232 phosphorylation, resulting in reduced aerobic glycolysis and cancer proliferation in cultures (1-10 µM) and in mice in vivo (40-80 mg/kg via daily i.p. injection; A549 & HT-29 xenografts). JX06 is shown to target PDK1 Cys240 for covalent modification.
Potent, PDK1-selective, covalent pyruvate dehydrogenase kinase (PDHK, PDK) inhibitor with anti-cancer efficacy in vitro and in vivo.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | S(SC(=S)N2CCOCC2)C(=S)N1CCOCC1 |
| InChI | 1S/C10H16N2O2S4/c15-9(11-1-5-13-6-2-11)17-18-10(16)12-3-7-14-8-4-12/h1-8H2 |
| InChI key | KKVYOWPPMNSLCP-UHFFFAOYSA-N |
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¥ 4968.78
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¥ 8982.64
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¥ 1568.60
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¥ 2307.00
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¥ 2099.27
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NALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/8 x 1/4 x 1/16，英寸，每箱数量50，50/箱，8000-0020，Thermofisher，赛默飞世尔询价
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¥ 4476.05
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¥ 165230.53
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¥ 75435.65
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¥ 51018.02
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¥ 58855.47
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