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Biochem/physiol Actions
Tilmicosin phosphate, a cell-permeable macrolide antibiotic with enhanced solubility and administration due to its phosphate salt, primarily targets bacterial 50S ribosomes, dose-dependently inhibiting protein synthesis. It is effective against Gram-positive bacteria, key Gram-negative respiratory pathogens like Pasteurella multocida (susceptible at ≤16 μg/ml) and Mannheimia haemolytica, and Mycoplasma species (e.g., M. gallisepticum MIC99 0.027 μg/mL), including notable activity against S. aureus (bovine mastitis MIC90 0.78 μg/mL versus native tilmicosin MIC 3.0 μg/mL), rendering it crucial for treating livestock respiratory diseases owing to its excellent lung penetration and prolonged half-life. Beyond selective antibacterial action, tilmicosin exhibits anti-inflammatory properties by modulating macrophage cytokine and gene expression (e.g., COX-2, iNOS).
Disclaimer
Hygroscopic, Store with desiccant
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
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¥ 2290.21
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¥ 8135.09
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¥ 238.17
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¥ 2617.87
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¥ 1509.00
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¥ 745.60
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¥ 5061.38
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