Icotinib，50MG，SML3725-50MG，Sigma

Biochem/physiol Actions

Icotinib is an orally active, potent and highly selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (IC50 = 5 nM) that inhibits EGFR-mediated intracellular tyrosine phosphorylation (IC50 = 45 nM; A431 cells) and cancer proliferation in cultures (A431/BGC-823 IC50 = 1.0/4.1 μM) and in vivo (30-120 mg/kg via daily p.o. to mice with A431, A549, H460 and HCT8 xenografts).
Orally active, potent and highly selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor with anti-cancer efficacy in vitro and in vivo.