- 商品介绍
- 规格参数
- 包装参数
General description
ERBB2 (erb-b2 receptor tyrosine kinase 2) is a tyrosine kinase receptor that belongs to the ErbB family. It is also known as HER2/Neu. It is located on chromosome 17q12.
Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.
Immunogen
Peptide sequence around aa. 1219-1223/1220-1224 (N-L-Y-Y -W), according to the protein ERBB2.
Biochem/physiol Actions
ERBB2 (erb-b2 receptor tyrosine kinase 2) is considered as a therapeutic target in breast cancer. It controls the concentration of intracellular calcium in SKBR3 (breast cancer cell line) cells.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | ~185 kDa |
| species reactivity | human |
| concentration | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100,indirect immunofluorescence: 1:100-1:200,western blot: 1:500-1:1000 |
| isotype | IgG |
| immunogen sequence | (N-L-Y-Y-W) |
| NCBI accession no. | NP_001005862.1 |
| UniProt accession no. | P04626 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... ERBB2(2064) |
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¥ 2013.69
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¥ 8520.40
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¥ 1568.60
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