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Biochem/physiol Actions
ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1).
ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). IC50 values were 11.1 nM and 6.4 nM in MDA-MB-231 and HEK 293T cells with no activity detected against >50 other serine hydrolases. PME-1 regulates the methylesterification state of protein phosphatase 2A (PP2A) and is implicated in cancer and neurodegeneration.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | film |
| color | colorless |
| solubility | DMSO: ≥5 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | O=C1[C@](C2=CC=CC=C2)(C3CCCC3)N(C(OC)=O)N1C(OC)=O |
| InChI | 1S/C17H20N2O5/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12/h3-5,8-9,13H,6-7,10-11H2,1-2H3/t17-/m0/s1 |
| InChI key | ZRHWCAFAIHTQKD-KRWDZBQOSA-N |
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¥ 2290.21
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¥ 2068.25
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¥ 4039.86
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¥ 4173.75
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¥ 3275.78
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¥ 3812.28
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