- 商品介绍
- 规格参数
- 包装参数
Application
SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2
Biochem/physiol Actions
SD-208 is TGF-βR I kinase inhibitor with IC50 =49 nM based on direct enzymatic assay of TGFRI kinase (ALK5) activity with a specificity of >100-fold against TGFRII and at least 17-fold over members of a panel of related protein kinases including p38a, p38b, p38d, JNK1, EGFR, MAPKAPK2, MKK6, ERK2, PKC, PKA, PKD, CDC2, and CaMKII.
SD-208 is a novel transforming growth factor beta receptor I (TGF-βR I) kinase inhibitor. SD-208 inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo.
SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | off-white to tan |
| solubility | DMSO: >5 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | Fc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2 |
| InChI | 1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25) |
| InChI key | BERLXWPRSBJFHO-UHFFFAOYSA-N |
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¥ 1573.49
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¥ 8293.41
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¥ 21702.96
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