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CD40-TRAF6 signaling inhibitor，5MG，SML1160-5MG，Sigma

销售价： ¥ 1015.25 / 件

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订货号： 0BQ2445

品牌型号： Sigma SML1160-5MG

货期：询货期

最小订货量： 1件

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产品介绍 Product Description

Application

CD40-TRAF6 signaling inhibitor has been used to treat human embryonic kidney (HEK)-293T cells to test its inhibitory effect on the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) leading to subsequent abrogation of (P2RY6)-dependent nuclear factor kappa B (NF-κB).

Biochem/physiol Actions

CD40-TRAF6 (cluster of differentiation 40-TNF receptor associated factor) signaling is recognized as an effective target in treating vascular disease.
CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40.
CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40. The compound inhibits CD40-induced production of IL-1b and IL-6 in primary macrophages. The compound reduces insulin resistance and adipose tissue inflammation in a mouse diet induced obesity model.

技术参数 Specifications

Quality Segment	100
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C
SMILES string	O=C(C1=CC=CC=C1)/C=N/C2=CC(C)=CC=C2C
InChI	1S/C16H15NO/c1-12-8-9-13(2)15(10-12)17-11-16(18)14-6-4-3-5-7-14/h3-11H,1-2H3/b17-11+
InChI key	WIFPLULEUNBSTE-GZTJUZNOSA-N

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