- 商品介绍
- 规格参数
- 包装参数
Application
Ibandronate sodium salt has been used to study its effect on the proliferation and ultrastructure of Leishmania and Giardia by the generation of concentration curves. It has also been used to elucidate the route by which nitrogen-containing bisphosphonates (N-BPs) enter the cytosol and inhibit their molecular target.
Biochem/physiol Actions
Ibandronate is a nitrogen-containing bisphosphonate (N-BP). It potentially inhibits mevalonate pathway in osteoclasts. Thus, ibandronate is effectively used to treat osteoporosis and other bone-related diseases.
Ibandronate sodium inhibits farnesyl diphosphate synthase (IC50 = 20 nM). Ibandronate sodium is also a bone resorption inhibitor. It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.
Ibandronate sodium is a farnesyl diphosphate synthase inhibitor (IC50 = 20 nM); also a bone resorption inhibitor.
Features and Benefits
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
| Quality Segment | 100 |
| assay | ≥97% (NMR) |
| form | solid |
| storage condition | protect from light |
| color | white |
| solubility | H2O: >10 mg/mL |
| originator | Roche |
| storage temp. | 2-8°C |
| SMILES string | [Na+].CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)([O-])=O |
| InChI | 1S/C9H23NO7P2.Na/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17;/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17);/q;+1/p-1 |
| InChI key | LXLBEOAZMZAZND-UHFFFAOYSA-M |
| Gene Information | human ... FDPS(2224) |
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