- 商品介绍
- 规格参数
- 包装参数
Application
Ciglitizone has been used as a proliferator-activated receptor γ (PPARγ) agonist:
- to study its effects on cell proliferation in human melanocytes
- to study its effects on pigmentation and migration of human melanocytes
It also may be used to study its effects on cell cycle and apoptosis in monocytic cells.
Biochem/physiol Actions
Ciglitizone belongs to the class of thiazolidinediones and is a peroxisome proliferator-activated receptor γ (PPARγ) agonist. It exhibits anti-diabetic activity. Ciglitizone has the potential to treat tumor necrosis factor α (TNFα)-related apoptosis-inducing ligand (TRAIL)-refractory high-grade urothelial cancers.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| originator | Takeda |
| SMILES string | CC1(CCCCC1)COc2ccc(CC3SC(=O)NC3=O)cc2 |
| InChI | 1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21) |
| InChI key | YZFWTZACSRHJQD-UHFFFAOYSA-N |
| Gene Information | human ... PPARG(5468) mouse ... Pparg(19016) |
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¥ 1048.84
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¥ 782.57
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¥ 2290.18
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