- 商品介绍
- 规格参数
- 包装参数
General description
Clemizole is a potent anti-allergic drug.
Biochem/physiol Actions
Clemizole is a potent and preferring inhibitor of TRPC5 that efficiently blocks heterologously expressed homomeric TRPC5 channels as well as heteromeric TRPC1:TRPC5 channels. Clemizole is a potent and selective H1 histamine receptor antagonist. Clemizole inhibited binding of HCV RNA by NS4B inhibit HCV RNA replication in cell culture.
Clemizole is a potent and preferring inhibitor of TRPC5; Antihistaminic.
Clemizole is an antihistamine and an inhibitor of NS4B (nonstructural protein 4B) RNA of HCV (hepatitis C virus). Studies in Scn1α (sodium channel, voltage-gated, type I, α) Zebrafish mutant show that this drug has the potential as a therapeutic agent in Dravet Syndrome treatment.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | H2O: 2 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| SMILES string | ClC(C=C1)=CC=C1CN2C(CN3CCCC3)=NC4=CC=CC=C42.[H]Cl |
| InChI | 1S/C19H20ClN3.ClH/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22;/h1-2,5-10H,3-4,11-14H2;1H |
| InChI key | DNFMJYXRIMLMBZ-UHFFFAOYSA-N |
| 长度(mm) | |
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¥ 2707.32
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¥ 1259.40
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¥ 1573.49
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¥ 1451.54
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¥ 2068.25
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¥ 3109.49
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¥ 3290.05
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¥ 4897.21
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¥ 2151.46
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¥ 1476.00
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¥ 1509.00
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¥ 2869.87
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¥ 3476.87
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