- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
Galunisertib (LY2157299) is an orally active multikinase inhibitor (IC50 in nM = 80/ALK4, 170/TGFβR1, 210/TGβ?R2, 190/MINK (MAP4K6), 220/RIP2 (RIPK2), 260/CK1α, 280/MEKKK4, 310/GAK, 400/CK1ε, 470/ALK6 (BMPR1B), 500/B-raf, 510/TNIK) mostly cited for its ALK4 & TGFbeta (TGFβ) receptors (TGFβ-RI (ALK5) & TGFβ-RII) inhibitory activity and anticancer efficacy in vitro (0.1-10 μM) and in vivo (20-100 mg/kg p.o.; mice).
Orally active multikinase inhibitor best known for its ALK4, TGFbeta receptors TGFβ-RI (ALK5) & TGFβ-RII activity and anticancer efficacy in vitro and in vivo.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | [n]21nc(c(c2CCC1)c4c5c(ncc4)ccc(c5)C(=O)N)c3nc(ccc3)C |
| InChI | 1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28) |
| InChI key | IVRXNBXKWIJUQB-UHFFFAOYSA-N |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
询价
-
¥ 1148.92
-
询价
-
¥ 2814.26
-
¥ 1563.36
-
询价
-
¥ 2068.25
-
¥ 3109.49
-
¥ 4039.86
-
询价
-
询价
-
询价
-
询价
-
询价
-
询价
-
询价
-
¥ 8520.40
-
¥ 3275.78
-
询价
微信小程序
7X24小时在线咨询