首页> 化学试剂> 其他化学试剂> 其他> Monosialoganglioside GM1 from bovine brain，1MG，G9652-1MG，Sigma

收藏产品

Monosialoganglioside GM1 from bovine brain，1MG，G9652-1MG，Sigma

销售价： ¥ 1985.87 / 件

在线询价

优惠：请询价

订货号： 0BP7725

品牌型号： Sigma G9652-1MG

货期：询货期

最小订货量： 1件

+ -

加入购物车

联系我们

400-920-3909

微信扫一扫，手机采购

精选商品

ITS液体培养基补充剂（100x），I3146-5ML，Sigma

销售价： ¥ 706.75

加入购物车

LookOut DNA Erase，250 mL，L8917-250ML

销售价： ¥ 670.73

加入购物车

F-12培养基,N4888-6X500ML,Sigma

销售价： ¥ 2367.14

加入购物车

潮霉素B，20ML，10843555001，Roche

销售价： ¥ 2550.13

加入购物车

NADPH，1G，10621706001，Roche

销售价： ¥ 27460.69

加入购物车

光溜海绵素C，10UG，X2628-10UG，Sigma

销售价： ¥ 4893.32

加入购物车

商品介绍
规格参数
包装参数

产品介绍 Product Description

General description

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum. They contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage. For classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

Application

Specific receptors for cholera toxin that accumulate in the brain in late infantile lipidosis.

Biochem/physiol Actions

Monosialoganglioside GM1 is a major sialoglycolipid of neuronal membranes that modulates calcium homeostasis. It binds to cholera toxin B subunit, resulting in stimulation of adenylate cyclase in a wide variety of cell types. After cholera toxin binds to membrane associated monosialoganglioside GM1, the A subunit of cholera toxin is translocated to the cell interior, where it catalyzes the ADP ribosylation of the membrane associated Gs subunit of adenylate cyclase. In addition, binding of cholera toxin to monosialoganglioside GM1 causes translocation of NF-κB and activation of dendritic cells.

Monosialoganglioside GM1 was one of many mono- and oligosaccharide ligands studied for their affinity for NKR-P1, a membrane protein on natural killer cells, which contains an extracellular Ca2+-dependent lectin domain. Monosialoganglioside GM1 is effective in partially correcting the consequences of neuroinjury in a number of in vivo and in vitro model systems.

Preparation Note

Monosialoganglioside GM1 is prepared by a modification of a published procedure. It is isolated from bovine brain by extraction and solvent fractionation methods. The final purification is done by HPLC on silica gel allowing no buffer salts to be used for the purification.

技术参数 Specifications

Quality Level	200
sterility	γ-irradiated
product line	BioXtra
assay	≥95% (TLC)
form	lyophilized powder
mol wt	~1540
technique(s)	blocking: suitable
impurities	endotoxin, tested
solubility	chloroform/methanol: 9.80-10.20 mg/mL, clear to slightly hazy, colorless to light yellow
storage temp.	−20°C
SMILES string	CCCCCCCCCCCCCCCCCCCC(=O)N[C@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O)[C@H]3NC(C)=O)[C@H](O[C@@]5(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O5)[C@H](O)[C@H](O)CO)C(O)=O)[C@H]2O)[C@H](O)[C@H]1O)[C@@H](O)\C=C\CCCCCCCCCCCCCCC
InChI	1S/C73H131N3O31/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-52(86)76-44(45(83)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)40-99-69-61(93)59(91)63(50(38-79)102-69)104-71-62(94)67(98-41-47(85)55(87)66-53(74-42(3)81)46(84)35-73(97,107-66)72(95)96)64(51(39-80)103-71)105-68-54(75-43(4)82)65(57(89)49(37-78)100-68)106-70-60(92)58(90)56(88)48(36-77)101-70/h31,33,44-51,53-71,77-80,83-85,87-94,97H,5-30,32,34-41H2,1-4H3,(H,74,81)(H,75,82)(H,76,86)(H,95,96)/b33-31+/t44?,45?,46-,47?,48+,49+,50+,51+,53+,54+,55?,56-,57-,58-,59+,60+,61+,62+,63+,64-,65+,66+,67+,68-,69+,70-,71-,73-/m0/s1
InChI key	CNLVNZJJSHZYAS-ALSOZVJRSA-N

长度(mm)
宽度(mm)
高度(mm)
重量(kg)