- 商品介绍
- 规格参数
- 包装参数
General description
Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signalling stimulated by IL-4R leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4R signaling have been reported in cancers of breast, liver and renal cells
Anti-Interleukin-4 soluble receptor specifically recognizes human cell surface IL-4R.
Immunogen
recombinant human IL-4 soluble receptor (IL-4 sR), expressed in Sf 21 insect cells.
Application
Anti-Interleukin-4 soluble receptor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For ELISA, a working concentration of 0.5-1.0 μg/ml is recommended. The antibody is suitable for neutralization reactions at a working concentration of 5-10 μg/ml. This antibody was used for immunostaining of parasympathetic neurons from guinea pig and human neuroblastoma cells at a dilution of 1:200.
Biochem/physiol Actions
The antibody will neutralize human cell surface IL-4 receptor mediated-bioactivity.
Physical form
Lyophilized from 51.5 μL of a 0.2μm filitered solution in PBS (pH7.4) with 5% trehalose.
Preparation Note
Purified using Protein G.
| biological source | goat |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | lyophilized powder |
| species reactivity | human |
| technique(s) | indirect ELISA: suitable,neutralization: suitable,western blot: suitable |
| UniProt accession no. | P24394 |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... IL4R(3566) |
| 长度(mm) | |
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¥ 629.40
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¥ 1349.07
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无菌，PETG 方形有刻度培养基瓶，带盖，聚对苯二酸乙二醇酯共聚物，天然高密度聚乙烯盖，500毫升容量，每箱40，40/箱，342020-0500，Nalgene，Thermofisher，赛默飞世尔¥ 1473.74
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¥ 968.94
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¥ 502.32
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¥ 2005.84
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¥ 839.71
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¥ 1101.77
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