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Biochem/physiol Actions
Cell permeable degrader of splicing factor 3B1 (SF3B1)
SF3B1 Protein degrader (reported as "PROTAC-O4I2" in Gama-Brambila et al.) is a cell permeable degrader of splicing factor 3B1 (SF3B1) containing an SF3B1 activator O4I2 connected to the ligand of the cereblon ubiquitin ligase thalidomide. PROTAC-O4I2 selectively degrades SF3B1 in cells. It induces apoptosis of tumor cells and extends survival in Drosophila intestinal tumor model.
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | powder |
| storage condition | under inert gas |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | O=C1N(C(C2=C1C=CC=C2NCCCCCCNC(C3=CSC(NC4=CC=C(C=C4)Cl)=N3)=O)=O)C5CCC(NC5=O)=O |
| InChI key | UWYLVQJEOCYCEW-UHFFFAOYSA-N |
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