- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
Asunaprevir (ASV; BMS-650032) is an orally active, potent and selective hepatitis C virus (HCV) NS3 protease inhibitor (HCV NS3/4A IC50 = 0.7 nM; GBV-B NS3/4A IC50 = 21 µM, IC50 >5 µM using 11 human serine and cysteine proteases) that targets the NS3/4A protease complex with high affinity (Ki = 0.4 and 0.24 nM, using genotypes 1a (H77) and 1b (J4L6S), respectively). ASV inhibits HCV replication in cultures (IC50 = 1-4 nM/replicon genotypes 1 & 4, 67 nM-1.162 µM/replicon genotypes 2 & 3, >12 μM against a panel of other RNA viruses).
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | CC(C)(C)[C@@H](C(=O)N1C[C@@H](C[C@H]1C(=O)N[C@@]2(C[C@H]2C=C)C(=O)NS(=O)(=O)C3CC3)OC4=NC=C(C5=C4C=C(C=C5)Cl)OC)NC(=O)OC(C)(C)C |
| InChI | 1S/C35H46ClN5O9S/c1-9-19-16-35(19,31(44)40-51(46,47)22-11-12-22)39-28(42)25-15-21(49-29-24-14-20(36)10-13-23(24)26(48-8)17-37-29)18-41(25)30(43)27(33(2,3)4)38-32(45)50-34(5,6)7/h9-10,13-14,17,19,21-22,25,27H,1,11-12,15-16,18H2,2-8H3,(H,38,45)(H |
| InChI key | XRWSZZJLZRKHHD-QGQNBIQGSA-N |
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¥ 1779.22
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¥ 2842.54
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¥ 4020.77
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¥ 3896.11
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¥ 3476.87
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