Anti-CCM2 antibody produced in goat，100UG，SAB2500214-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Cerebral cavernous malformation 2 (CCM2) is an adaptor protein consisting of two domains. Structurally, it has two domains, N-terminal phosphotyrosine-binding (PTB) domain and an independent domain named as Karet domain at the C-terminal end. It is mapped on human chromosome 7p. Its phosphotyrosine-binding (PTB) domain has the ability to bind proteins. It is expressed in vascular endothelium and neuroglial precursor cells during development and also observed in arterial endothelium, neurons, and some of the glial cells in adult neocortex.

Immunogen

Peptide with sequence C-KGEKSRDKKAHEK from the internal region of the protein sequence according to NP_001025006.1; NP_113631.1.

Application

Anti-CCM2 antibody produced in goat is suitable for indirect ELISA and western blot assay.

Biochem/physiol Actions

Cerebral cavernous malformation 2 (CCM2) is associated with several cellular pathways. It mainly behaves as a scaffold protein in the activation of GTPase Rac-dependent p38 mitogen-activated protein kinase (MAPK) during hyperosmotic stress. It also participates in vascular integrity. CCM2 may play a role in vasculogenesis and angiogenesis during the development of the brain. Mutation in the gene is associated with familial cerebral cavernous malformations.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

技术参数 Specifications

biological source	goat
Quality Segment	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	buffered aqueous solution
species reactivity	rat, human, mouse, canine
technique(s)	indirect ELISA: suitable,western blot: suitable
UniProt accession no.	Q9BSQ5
shipped in	dry ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... CCM2(83605)

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