- 商品介绍
- 规格参数
- 包装参数
Application
TRKA (440-end), active, GST tagged human was used to study functional NGF signal transduction.
Biochem/physiol Actions
TRKA (440-end), active, GST tagged human is a 140 kD membrane-spanning protein tyrosine kinase that belongs to proto-oncogene family. TRKA facilitates the regulation of cell differentiation and survival via activating SHC1 and FRS2 which in turn activates a GRB2-Ras-MAPK cascade. It also plays a pivotal role in controlling NF-κ-B activation as well as transcription of genes involved in cell survival via PLCG1.
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
| biological source | human |
| Quality Segment | 200 |
| recombinant | expressed in baculovirus infected Sf9 cells |
| product line | PRECISIO® Kinase |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| specific activity | 19-25 nmol/min·mg |
| mol wt | ~66 kDa |
| technique(s) | activity assay: suitable |
| UniProt accession no. | P04629 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... NTRK1(4914) |
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¥ 580.62
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¥ 1669.50
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¥ 2757.88
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¥ 1958.88
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¥ 1761.75
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¥ 478.46
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¥ 911.06
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¥ 15537.49
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¥ 17652.29
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