- 商品介绍
- 规格参数
- 包装参数
Application
GSK690693 has been used in western blotting and immunoprecipitations.
Biochem/physiol Actions
4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol/GSK690693 is a protein kinase B/AKT inhibitor. GSK690693 can prevent growth and apoptosis in acute lymphoblastic leukemia cell lines.
GSK690693 is a potent pan-AKT kinase inhibitor.
GSK690693 is an ATP competitive, potent pan-AKT kinase inhibitor with IC50 values of 2, 13, and 9 nM against AKT1, 2, and 3, respectively.
Features and Benefits
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 5 mg/mL (clear solution) |
| storage temp. | 2-8°C |
| SMILES string | CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c4nonc4N |
| InChI | 1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 |
| InChI key | KGPGFQWBCSZGEL-ZDUSSCGKSA-N |
| Gene Information | human ... AKT1(207), AKT2(208), AKT3(10000), PRKACA(5566), PRKACB(5567), PRKACG(5568), PRKCA(5578), PRKCB(5579), PRKCD(5580), PRKCE(5581), PRKCG(5582), PRKCH(5583), PRKCI(5584), PRKCQ(5588), PRKCZ(5590), PRKD1(5587), PRKD3(23683) |
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¥ 2528.88
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¥ 1259.40
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¥ 2013.69
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¥ 1302.89
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¥ 4039.86
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¥ 8135.09
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¥ 3290.05
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¥ 3812.28
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¥ 4897.21
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¥ 2268.97
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