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Biochem/physiol Actions
The complement system is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the inflammatory response, phagocyte chemotaxis and opsonization, and cell lysis.
A complex of complements C5b, C6, C7, and C8 mediates the polymerization of up to eighteen C9 molecules into a tube-like membrane attack complex that is inserted into the plasma membrane of unwanted organisms, such as of Gram-negative bacteria and viral infected cells. This channel through the lipid bilayer results in lysis of the cell.
Human Complement C7 is a β-2-globulin, which is composed of a single polypeptide chain. The initial binding of C7 and C6 to C5b is thought to form a stable complex for subsequent binding of C8 and C9. The resulting activated complex is responsible for membrane attack and lysis.
Analysis Note
Functionally active by a sensitive hemolytic assay.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
| biological source | human serum |
| Quality Level | 200 |
| assay | ≥85% (SDS-PAGE) |
| form | solution |
| specific activity | ≥150,000 C7H50 units/mg protein |
| concentration | 1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2 |
| technique(s) | activity assay: suitable |
| UniProt accession no. | P10643 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... C7(730) |
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