- 商品介绍
- 规格参数
- 包装参数
General description
Histones are highly basic chromatin proteins. They tightly pack and organize eukaryotic DNA to form nucleosomes. A nucleosome comprises an octameric core histone made of a tetramer of histones H3 and H4 with two dimers of histones H2A and H2B. The 147 DNA base pairs are wrapped around the histone complex. H2A consists of a C-terminal tail extending out of the nucleosome core particle.
Application
Histone H2A human has been used as a neutrophil extracellular trap (NET) to study its effects on the membrane integrity and viability of macrophages (MFS) and dendritic cells (DCS). It has also been used in far-western blot analysis for protein identification.
Biochem/physiol Actions
Histones modulate the accessibility of DNA during transcription, DNA replication, DNA repair, and recombination. N and C terminal tails undergo post-translational modifications (PTMs) altering DNA wrapping and chromatin regulation.
Physical form
Supplied in 20 mM Na3PO4, pH 7.0, 0.3 M NaCl and 1 mM EDTA
| biological source | human |
| Quality Level | 200 |
| recombinant | expressed in E. coli |
| form | liquid |
| concentration | 1 mg/mL |
| UniProt accession no. | Q16777 |
| application(s) | cell analysis |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | human ... H2AC20(8338) |
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¥ 1011.55
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¥ 638.71
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¥ 916.08
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¥ 1615.94
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¥ 1153.44
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¥ 661.45
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¥ 1958.88
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¥ 1029.59
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¥ 1066.63
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¥ 3254.85
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¥ 911.06
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¥ 1790.42
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¥ 1101.77
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¥ 21144.84
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¥ 25801.21
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