- 商品介绍
- 规格参数
- 包装参数
Application
LM22A-4 has been used as a component of dissociation medium for mouse embryonic stem cells (mESC) and human embryonic stem (hESC) aggregates.
Biochem/physiol Actions
LM22A-4 is a non-peptide and shares similarity with brain-derived neurotrophic factor (BDNF), especially in the loop2 region. It improves oligodendroglia density and favors myelin repair. LM22A-4 elevates the expression of protein kinase B (PKB or Akt) and extracellular signal-regulated kinases (ERKs). LM22A-4 elicits neuroprotection in spinal cord injury (SCI) by deregulating the cleaved-caspase-3 and favoring B-cell lymphoma 2(Bcl-2) expression.
LM22A-4 is a partial agonist of TrkB, a brain-derived neurotrophic factor (BDNF) receptor. In binding assays, LM22A-4 displaces BDNF with an IC50 of 47 nM. The compound restores TrkB phosphorylation and respiratory function in a mouse model of Rett syndrome.
LM22A-4 is a partial agonist of TrkB.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | H2O: 2 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| SMILES string | N(CCO)C(=O)c1cc(cc(c1)C(=O)NCCO)C(=O)NCCO |
| InChI | 1S/C15H21N3O6/c19-4-1-16-13(22)10-7-11(14(23)17-2-5-20)9-12(8-10)15(24)18-3-6-21/h7-9,19-21H,1-6H2,(H,16,22)(H,17,23)(H,18,24) |
| InChI key | RGWJKANXFYJKHN-UHFFFAOYSA-N |
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¥ 2707.32
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¥ 1259.40
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¥ 1451.54
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¥ 3442.25
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¥ 1564.00
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¥ 1586.69
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¥ 3476.87
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