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Biochem/physiol Actions
Brain tissue penetrant alpha-synuclein ligand that potently disaggregate alpha-synuclein fibrils in vitro and in vivo models.
CNS-11 is brain tissue penetrant alpha-synuclein ligand that potently disaggregate alpha-synuclein fibrils in vitro and in vivo models. CNS-11 inhibits intracellular seeding of a-synuclein fibrils in biosensor cells—HEK293T cells. C-11 reduces number of a-synuclein aggregates in C. elegans model.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear (Warmed) |
| storage temp. | 2-8°C |
| SMILES string | O=C1C2=C(C(C3=C4C=CC=C3)=NN1CC(NC5=C(C)C=C(C)C=C5C)=O)C4=CC=C2 |
| InChI key | MVMNMAWCMNMLEC-UHFFFAOYSA-N |
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