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VU0360172 hydrochloride，25MG，SML3230-25MG，Sigma

销售价： ¥ 2847.17 / 件

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订货号： 0BP1724

品牌型号： Sigma SML3230-25MG

货期：询货期

最小订货量： 1件

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产品介绍 Product Description

General description

VU0360172 is a potent (EC50 = 16.6 nM), systemically active positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 5 (mGlu5). It is the first orally active mGlu5 PAM to be efficacious in an in vivo preclinical antipsychotic model, producing a dose-dependent reversal of amphetamine-induced hyperlocomotion. It was also found to reduce spontaneous absence seizures in WAG/Rij rats and to inhibit pain. Reduced spontaneous spike and wave discharges without impacting motor behavior in a rat model of absence epilepsy have been observed.

Biochem/physiol Actions

Potent, systemically active mGluR5 PAM
VU0360172 is a potent (EC50 = 16.6 nM), systemically active positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 5 (mGlu5). It is the first orally active mGlu5 PAM to be efficacious in an in vivo preclinical antipsychotic model, producing a dose-dependent reversal of amphetamine-induced hyperlocomotion. It was also found to reduce absence seizures in WAG/Rij rats and to inhibit pain.

技术参数 Specifications

Quality Level	100
assay	≥98% (HPLC)
form	powder
storage condition	desiccated
color	white to beige
solubility	DMSO: 2 mg/mL, clear (warmed)
storage temp.	−20°C
SMILES string	FC1=CC=CC(C#CC2=NC=C(C=C2)C(NC3CCC3)=O)=C1.Cl
InChI	1S/C18H15FN2O.ClH/c19-15-4-1-3-13(11-15)7-9-16-10-8-14(12-20-16)18(22)21-17-5-2-6-17;/h1,3-4,8,10-12,17H,2,5-6H2,(H,21,22);1H
InChI key	NBGAPTWZQXSEAA-UHFFFAOYSA-N

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