- 商品介绍
- 规格参数
- 包装参数
产品介绍
Product Description
Biochem/physiol Actions
Antiproliferative mTORC1 inhibitor
Ridaforolimus is an antiproliferative mTOR inhibitor that forms a complex with the FK506 binding protein-12 (FKBP-12), which binds to and inhibits mTOR resulting in cell cycle arrest and inhibition of tumor cell growth and proliferation. Like rapamycin, ridaforolimus affects only mTORC1, not mTORC2.
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥95% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
| SMILES string | O=C(N1CCCC[C@]12[H])C([C@@]3(O)[C@@H](CC[C@]([H])(O3)C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@H](C([C@@H]([C@H](O)/C(C)=C/[C@H](C(C[C@@]([H])([C@@H](C[C@H]4C[C@@H](OC)[C@@H](CC4)OP(C)(C)=O)C)OC2=O)=O)C)OC)=O)C)C)=O |
| InChI | 1S/C53H84NO14P/c1-32-18-14-13-15-19-33(2)44(63-8)30-40-23-21-38(7)53(61,67-40)50(58)51(59)54-25-17-16-20-41(54)52(60)66-45(35(4)28-39-22-24-43(46(29-39)64-9)68-69(11,12)62)31-42(55)34(3)27-37(6)48(57)49(65-10)47(56)36(5)26-32/h13-15,18-19,27,32,34-36,38-41,43-46,48-49,57,61H,16-17,20-26,28-31H2,1-12H3/b15-13+,18-14+,33-19+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1 |
| InChI key | BUROJSBIWGDYCN-GAUTUEMISA-N |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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