- 商品介绍
- 规格参数
- 包装参数
General description
Takinib belongs to the aminobenzimidazole class of inhibitors.
Application
Takinib has been used as an inhibitor of transforming 28 growth factor - β-activated kinase -1 (TAK-1) in human leukemia monocytic THP-1 cells. It may be used as a TAK1 inhibitor in Jurkat cells.
Biochem/physiol Actions
TAK-1 inhibitor
Takinib is a selective inhibitor of TAK1/MAP3K7 kinase, which is a member of the MAP3K family and a key regulator of cell death. It binds in the TAk1 ATPbinding pocket with an IC50 value of 9.5 nM. Takinib selectively induced apoptosis following TNF-α stimulation in rheumatoid arthritis and breast cancer.
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | CCCN1C2=CC=CC=C2N/C1=N\C(C3=CC(C(N)=O)=CC=C3)=O |
| 长度(mm) | |
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¥ 503.76
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¥ 746.52
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¥ 827.30
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¥ 1958.88
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¥ 6085.86
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无菌，PETG 方形有刻度培养基瓶，带盖，聚对苯二酸乙二醇酯共聚物，天然高密度聚乙烯盖，500毫升容量，每箱40，40/箱，342020-0500，Nalgene，Thermofisher，赛默飞世尔¥ 1473.74
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¥ 907.59
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¥ 1327.84
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¥ 1147.95
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¥ 915.42
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询价
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¥ 56581.65
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