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- 规格参数
- 包装参数
Application
Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.
Biochem/physiol Actions
A non-sedating H1-receptor antagonist, free from antimuscarinic/anticholinergic effects. It has novel antiallergic and anti-inflammatory effects.
Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.
Legal Information
Clarinex is a registered trademark of Schering Corp.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| solubility | DMSO: >10 mg/mL |
| storage temp. | 2-8°C |
| SMILES string | Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1 |
| InChI | 1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2 |
| InChI key | JAUOIFJMECXRGI-UHFFFAOYSA-N |
| Gene Information | human ... HRH1(3269) |
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