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WZ4003，25MG，SML1445-25MG，Sigma

销售价： ¥ 4809.74 / 件

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订货号： 0BN6026

品牌型号： Sigma SML1445-25MG

货期：询货期

最小订货量： 1件

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商品介绍
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产品介绍 Product Description

Biochem/physiol Actions

Selective inhibitor of NUAK1 and NUAK2 kinases with an IC50 of 20 nM for NUAK1 and an IC50 of 100 nM for NUAK2
WZ4003 helps to repress the migration of cells. It also prevents cell proliferation.
WZ4003 is a potent and selective inhibitor of NUAK1 and NUAK2 kinases, members of the AMPK family that are that are activated by the LKB1 (liver kinase B1) tumour suppressor kinase and involved in development and proliferation. WZ4003 has an IC50 of 20 nM for NUAK1 and an IC50 of 100 nM for NUAK2 without significant inhibition of 139 other kinases tested, including ten AMPK-related kinase family members. Treatment with WZ4003 was found to suppress proliferation, restricting cells from entering into mitosis.

Other Notes

WZ4003 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the WZ4003 probe summary on the Chemical Probes Portal website.

技术参数 Specifications

Quality Level	100
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	−20°C
SMILES string	ClC1=CN=C(NC2=C(OC)C=C(N3CCN(C)CC3)C=C2)N=C1OC4=CC(NC(CC)=O)=CC=C4
InChI	1S/C25H29ClN6O3/c1-4-23(33)28-17-6-5-7-19(14-17)35-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)34-3)32-12-10-31(2)11-13-32/h5-9,14-16H,4,10-13H2,1-3H3,(H,28,33)(H,27,29,30)
InChI key	SDGJBAUIGHSMRI-UHFFFAOYSA-N

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