- 商品介绍
- 规格参数
- 包装参数
General description
Hsp90 (heat shock protein 90) is one of the most abundant chaperones in the cytosol of eukaryotic cells. It interacts with various proteins, including protein kinases and transcription factors, and either facilitates their stabilization and activation or directs them for proteasomal degradation. Hsp90 thus affects multiple signaling pathways and biological processes and modulation of this single target offers the prospect of simultaneous intervence to various key points of oncogenic transformation. Hsp90 operates as a dimer in a conformational cycle driven by ATP binding and hydrolysis. There are two isoforms, alpha and beta, of vertebrate Hsp90. Whereas Hsp90 beta is expressed constitutively to a high level, Hsp90 alpha is stress-inducible and is overexpressed in many cancerous cells.
Immunogen
Peptide corresponding to the sequence EEVHHGEEEVEC within N-terminal part of human Hsp90.
Biochem/physiol Actions
The antibody MBH90AB recognizes the epitope EEEVE within N-terminal part of ubiquitously expressed Hsp90 alpha and Hsp90 beta intracellular proteins with calculated Mw of 84.7 kDa and 83.3 kDa, respectively, however, migrating as 90 kDa bands under reducing SDS-PAGE conditions.
Physical form
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Preparation Note
Purified by protein-A affinity chromatography.
Store at 2-8°C. Do not freeze.
Other Notes
The antibody solution should be gently mixed before use.
| conjugate | unconjugated |
| Quality Level | 100 |
| antibody product type | primary antibodies |
| clone | MBH90AB, monoclonal |
| form | buffered aqueous solution |
| species reactivity | ( Mouse), ( Human), (Cow) |
| concentration | 1 mg/ml |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG1 |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
¥ 1779.22
-
询价
-
询价
-
询价
-
询价
-
询价
-
询价
-
¥ 3290.05
-
¥ 4897.21
-
无菌，PETG 方形有刻度培养基瓶，带盖，聚对苯二酸乙二醇酯共聚物，天然高密度聚乙烯盖，500毫升容量，每箱40，40/箱，342020-0500，Nalgene，Thermofisher，赛默飞世尔¥ 3684.34
-
¥ 2869.87
-
¥ 3476.87
-
¥ 9909.51
-
NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔询价
-
¥ 5990.26
-
¥ 37675.92
-
询价
-
¥ 58855.47
-
¥ 55311.07
微信小程序
7X24小时在线咨询