- 商品介绍
- 规格参数
- 包装参数
Application
SB-269970 hydrochloride has been used to study the effect of different endotype combination on the activity of the 5-hydroxytryptamine receptor of tall fescue alkaloids. It has also been used to inhibit dopamine receptor signaling, in order to study its role in early hemocyte activation.
SB-269970 was used to study the role of 5-HT7 receptors in serotonin-induced hypothermia in rodents.6
Biochem/physiol Actions
SB-269970 is an anti-psychotic agent that shows high affinity for 5-HT7 receptors. It may be effective in treating cognitive disabilities and schizophrenia-like deficits.4 SB-269970 desensitizes and decreases the excitatory effects of 5-HT7 receptors in rat hippocampus.5
Selective 5-HT7 serotonin receptor antagonist.
Legal Information
Sold with the permission of GlaxoSmithKline Pharmaceuticals
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| optical activity | [α]/D 75 to 90°, c = 1.0 in DMSO |
| storage condition | desiccated |
| solubility | H2O: 10 mg/mL, clear (warmed to 60 °C) |
| storage temp. | 2-8°C |
| SMILES string | Cl.CC1CCN(CC1)CC[C@H]2CCCN2S(=O)(=O)c3cccc(O)c3 |
| InChI | 1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1 |
| InChI key | XQCJOYZLWFNDIO-PKLMIRHRSA-N |
| Gene Information | human ... HTR7(3363) |
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