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Biochem/physiol Actions
KCC-07 is a brain penetrant, potent and selective inhibitor of MBD2 (methyl-CpG-binding domain protein 2) that inhibits binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. KCC-07 inhibits medulloblastoma cell proliferation, and inhibits tumor growth in mice xenograft models of medulloblastoma.
brain penetrant, potent and selective inhibitor of MBD2 that inducing anti-proliferative BAI1/p53/p21 signaling
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | OC1=CC(NC2=NC(C3=NC=CC=C3)=CS2)=CC=C1 |
| InChI key | GIGNWEDIMLUWCT-UHFFFAOYSA-N |
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¥ 2814.26
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¥ 14407.09
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¥ 4404.38
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¥ 1564.00
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¥ 1156.91
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¥ 3896.11
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