- 商品介绍
- 规格参数
- 包装参数
General description
VDR (vitamin D receptor) or vitamin D3 receptor is a member of the steroid and thyroid hormone receptors superfamily of trans-acting transcriptional regulatory factors. It is an intracellular polypeptide of 50-60 kDa. This receptor is composed of a highly conserved cysteine, lysine, and arginine-rich DNA-binding domain, and a hydrophobic ligand-binding domain in its C-terminal. It shares size and sequence similarity to thyroid hormone receptor. VDR gene is localized to human chromosome 12q12-q14.
Immunogen
The antiserum was produced against synthesized peptide derived from human Vitamin D Receptor around the phosphorylation site of Ser208.
Immunogen Range: 181-230
Biochem/physiol Actions
VDR (vitamin D receptor) binds with its ligand vitamin D3, and acts upon the target cell nuclei to induce various biological effects. Vitamin D3 is also thought to have immunomodulatory effects, and gene polymorphisms are linked with pertussis. The variants might affect the immune response and clinical outcome of Bordetella pertussis infection.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 48 kDa |
| species reactivity | mouse, rat, human |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:10000,immunofluorescence: 1:100-1:500,western blot: 1:500-1:1000 |
| NCBI accession no. | P11473 |
| UniProt accession no. | P11473 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer208) |
| Gene Information | human ... VDR(7421) |
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