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产品介绍
Product Description
Biochem/physiol Actions
Potent and selective HDAC11 inhibitor that effectively upregulates cellular serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level.
SIS17 is a potent and selective HDAC11 inhibitor (IC50 = 830 nM; IC50 >100 μM against HDAC1/4/8 or SIRT1/2/3/6) that effectively upregulates HDAC11 substrate, serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level in MCF7 cells (12.5 μM).
技术参数
Specifications
| Quality Level | 100 |
| assay | ≥95% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear (Warmed) |
| storage temp. | -10 to -25°C |
| SMILES string | [s]1c(ccc1)C(=O)NNCCCCCCCCCCCCCCCC |
| InChI | 1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24) |
| InChI key | HSHXDCVZWHOWCS-UHFFFAOYSA-N |
| 长度(mm) | |
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| 重量(kg) |
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