Monoclonal Anti-GABRB3 antibody produced in mouse，100UG，SAB5200049-100UG，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

The γ-aminobutyric acid type A receptor β3 subunit (GABRB3) gene with nine exons spanning 250kb, is mapped to human chromosome 15q12, a hot region of genomic rearrangements. The gene codes for β3 subunit of GABAA receptor, which belongs to the GABA (γ-aminobutyric acid) receptor gene family.

Immunogen

Fusion protein amino acids 370-433 of mouse GABA-A_r Beta3, Accession Number AAB60502.

Biochem/physiol Actions

γ-aminobutyric acid type A receptor β3 subunit (GABRB3) is a candidate gene for autism spectrum conditions (ASC). Alteration in the gene results in increased tactile sensitivity, or hypersensitivity. Overexpression of GABRB3 might be implicated in the pathogenesis of heroin dependence. Aberration or mutation of this gene leads to neurodevelopmental disorders, such as Angelman syndrome, Prader-Willi syndrome and schizophrenia. GABRB3 polymorphisms results in nonsyndromic cleft lip and/or palate (NSCL/P).
Detects ~55 kDa. No cross-reactivity against GABA-A-R-Beta 2 or –Beta1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	mouse
Quality Level	100
conjugate	unconjugated
antibody form	purified immunoglobulin
antibody product type	primary antibodies
clone	S87-25, monoclonal
form	buffered aqueous glycerol solution
mol wt	antigen predicted mol wt 55 kDa
species reactivity	human, mouse, rat
concentration	1 mg/mL
technique(s)	immunocytochemistry: suitable,western blot: suitable
isotype	IgG1
NCBI accession no.	NP_032097.1
UniProt accession no.	P28472
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	mouse ... Gabrb3(14402)

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