- 商品介绍
- 规格参数
- 包装参数
Application
Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation1. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation2.
Biochem/physiol Actions
Inhibits the tyrosine kinase activity of the nerve growth factor receptor (TrkA; pp140trk) and heregulin receptor erbB-2 (HER-2).
Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells3. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice4.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Preparation Note
Tyrphostin AG 879 is soluble in DMSO at 26/ml and is insoluble in water.
| Quality Level | 100 |
| assay | 99% (HPLC) |
| solubility | DMSO: soluble (at 26 mg/ml),H2O: insoluble |
| SMILES string | CC(C)(C)c1cc(\C=C(/C#N)C(N)=S)cc(c1O)C(C)(C)C |
| InChI | 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+ |
| InChI key | XRZYELWZLNAXGE-KPKJPENVSA-N |
| Gene Information | human ... ERBB2(2064), NTRK1(4914) |
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¥ 1451.54
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¥ 3152.47
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¥ 5725.45
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