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Anti-Sonic Hedgehog peptide (C-terminal) antibody produced in goat，100UG，S9822-100UG，Sigma

销售价： ¥ 5926.10 / 件

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订货号： 0BN3450

品牌型号： Sigma S9822-100UG

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最小订货量： 1件

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产品介绍 Product Description

General description

The Hedgehog (Hh) family of secreted proteins consists of sonic hedgehog (Shh), desert hedgehog (Dhh) and Indian hedgehog (Ihh). The Hh signaling regulates cell migration and tissue construction during embryogenesis and reconstruction in adults. Shh protein is secreted by Purkinje cells in the cerebellum with both autocrine and paracrine functions. The Shh signaling is mediated by the interaction of Shh with transmembrane proteins, Patched and Smoothened. The Shh pathway cross-talks Notch and Wnt pathways and acts via downstream targets such as cyclins, γ catenin, myc and other transcription factors. The Hh family members have multiple roles as morphogens, cell survival factors, setting anterior-posterior axis and digit formation during development of limb and axon guidance factors during the development of brain and nervous system. Hedgehog signaling has been implicated in childhood tumors of pancreas, liver, thyroid, gastrointestinal tract, neuroblastomas and medulloblastomas
Anti-Sonic Hedgehog Peptide (C-terminal) recognizes mouse Sonic Hedgehog C-terminal peptide. This antibody shows less than 5% cross-reactivity with rmDhh C-terminal peptide and less than 1% cross-reactivity with a 6X histidine-tagged rmShh N-terminal peptide (amino acids 25-198).

Immunogen

purified, E. coli-derived recombinant mouse 6× histidine-tagged sonic hedgehog C-terminal peptide.

Application

Anti-Sonic Hedgehog Peptide (C-terminal) can be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For immunohistochemistry, a working concentration of 15 μg/ml is recommended.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

技术参数 Specifications

biological source	goat
Quality Level	100
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	polyclonal
form	lyophilized powder
species reactivity	mouse
technique(s)	immunohistochemistry: 15 μg/mL,western blot: 0.1-0.2 μg/mL
UniProt accession no.	Q62226
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	mouse ... Shh(20423)

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