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Biochem/physiol Actions
TC3.6 is a PDE7 selective inhibitor (IC50 = 1.04 μM). In an Experimental Autoimmune Encephalomyelitis (EAE) murine model, TC3.6 reduced levels of IL-17, blocked infiltration of immune cells into the CNS and elevated levels of the Treg marker Foxp3. TC3.6 also enhances survival and differentiation of oligodendrocyte precursor cells.
TC3.6 is a PDE7 selective inhibitor.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | light orange to dark orange |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | Sc1[n]([c](c3c(n1)cccc3)=S)c2ccccc2 |
| InChI key | DJJOAJCVIYRELX-UHFFFAOYSA-N |
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