Anti B cell linker Antibody, clone 23GB2990, Rabbit Monoclonal，1004G，SAB6012010-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
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Immunogen

A synthesized peptide corresponding to a sequence within amino acids 401-456 of human BLNK [NP_037446.1].

Physical form

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.

Other Notes

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

技术参数 Specifications

biological source	rabbit (Monoclonal)
Quality Level	100
recombinant	expressed in HEK 293 cells
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	23GB2990, recombinant monoclonal
form	buffered aqueous glycerol solution
mol wt	50 kDa
species reactivity	human, rat
packaging	vial of 1.5 mL
enhanced validation	recombinant expression Learn more about Antibody Enhanced Validation
sustainability	Greener Alternative Product
concentration	0.333 mg/ml
technique(s)	immunofluorescence: 1:100-:1000,western blot: 1:1,000-1:5,000
isotype	IgG
Ensembl \| human accession no.	ENSG00000095585
NCBI accession no.	NP_037446.1
UniProt accession no.	Q8WV28
greener alternative category	DfS-Developed
shipped in	wet ice
storage temp.	−20°C
target post-translational modification	unmodified
Gene Information	human ... BLNK(29760)

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