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Biochem/physiol Actions
HIV and HBV reverse transcriptase inhibitor tenofovir isopropylalaninyl phenyl ester with greater antiviral efficacy than tenofovir disoproxil fumarate.
Tenofovir alafenamide (TAF; GS-7340) is an isopropylalaninyl phenyl ester prodrug of the nucleotide analog reverse transcriptase inhibitor (nRTI) tenofovir (TFV) against human immunodeficiency virus (HIV) and hepatitis B virus (HBV). GS-7340 more efficiently delivers TFV into lymphoid cells and tissues than tenofovir disoproxil fumarate (TDF), resulting in greater antiviral efficacy against HIV.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | CC(OC([C@@H](N[P@](CO[C@@H](CN1C2=NC=NC(N)=C2N=C1)C)(OC3=CC=CC=C3)=O)C)=O)C |
| InChI | 1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1 |
| InChI key | LDEKQSIMHVQZJK-CAQYMETFSA-N |
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