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- 规格参数
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General description
Chemical structure: tetracycline
Biochem/physiol Actions
Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.
Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.
| assay | 89.5-102.0% anhydrous basis |
| Quality Level | 200 |
| form | powder or crystals |
| technique(s) | cell culture | mammalian: suitable |
| solubility | soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid) |
| antibiotic activity spectrum | Gram-negative bacteria,Gram-positive bacteria |
| mode of action | protein synthesis | interferes |
| storage temp. | −20°C |
| SMILES string | Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O |
| InChI | 1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1 |
| InChI key | GVSJQNRGSCOSNJ-KBHRXELFSA-N |
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¥ 3152.47
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¥ 15214.65
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¥ 3319.60
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¥ 1749.15
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¥ 67162.32
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¥ 26846.31
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¥ 30616.15
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¥ 41825.84
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¥ 15894.19
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¥ 205945.25
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