Pimelic Diphenylamide 106，25MG，SML0313-25MG，Sigma

Biochem/physiol Actions

Pimelic diphenylamides has the ability to enhance the expression of the frataxin gene in lymphocytes from Friedreich ataxia patients.
106 is a Class I HDAC inhibitor, demonstrating no activity against class II HDACs. It is a slow, tight-binding inhibitor of HDACs 1, 2, and 3, with a preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1.
106 is a potent Class I HDAC inhibitor, demonstrating no activity against class II HDACs.