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Biochem/physiol Actions
BTZ043 is the first in a new class of antibiotics that kills all clinically relevant strains of Mycobacterium Tuberculosis, including multi-drug resistant strains, with minimal inhibitory concentrations (MIC) in the ng/ml range (MIC = 2.3 nM against M. tuberculosis H37Rv and 9.2 nM against M. smegmatis). BTZ043 potently inhibits the enzyme decaprenylphosphoryl-β-D-ribose 2’-epimerase (DprE1), which is essential for the formation of decaprenylphosphoryl arabinose, a key component in cell wall synthesis. It appears that BTZ-043 diffuses and accumulates in centrally necrotizing granulomas (necrotic lesions) harboring Mycobacterium tuberculosis.
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | -10 to -25°C |
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| 重量(kg) |
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