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Biochem/physiol Actions
MG149 is cell-permeable anacardic acid analog that displays higher selectivity towards MYST type HATs (IC50 = 47 and 74 μM against MOF and Tip60; Ki for KAT8 = 39 μM) over p300 and PCAF (IC50 > 200 and >> 200 uM). Tip60 inhibition is shown to be Ac-CoA competitive and histone substrate non-competitive and KAT8 inhibition is Ac-CoA uncompetitive. MG149 treatment lowers histone acetylation levels and cellular proliferation rate, induces apoptosis and dose-dependently alters pro-inflammatory cytokines/chemokines expression. Enhances JQ1-induced HIV latency reversal, suppresses NOX transcription and ameliorates ROS levels.
cell-permeable anacardic acid analog that displays higher selectivity towards MYST type HATs over p300 and PCAF
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | OC1=C(C(CCC2=CC=C(C=C2)CCCCCCC)=CC=C1)C(O)=O |
| InChI | 1S/C22H28O3/c1-2-3-4-5-6-8-17-11-13-18(14-12-17)15-16-19-9-7-10-20(23)21(19)22(24)25/h7,9-14,23H,2-6,8,15-16H2,1H3,(H,24,25) |
| InChI key | WBHQYBZRTAEHRR-UHFFFAOYSA-N |
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¥ 4039.86
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¥ 8520.40
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¥ 3275.78
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¥ 6330.00
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¥ 4390.38
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¥ 1653.62
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¥ 44224.19
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