5-Ethyl-2′-deoxyuridine,250MG,E9386-250MG,Sigma

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订货号 0BM4307
品牌型号 Sigma E9386-250MG
货期 询货期
最小订货量 1件
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产品介绍 Product Description

Biochem/physiol Actions

5-Ethyl-2′-deoxyuridine is an analog of pyrimidine, uridine. It is an effective antiviral agent and inhibits cell division in leukemic tumor cells. 5-Ethyl-2′-deoxyuridine interacts with 2′-deoxycytidine phosphate (dCTP) biosynthesis pathway to elicit antiproliferative effects.
5-Ethyl-2′-deoxyuridine (EUdR) is used as a 5-fluorouracil (FU) modulator. EtdUrd may be used to enhance the therapeutic index of 5-FU by reducing the catabolism, prolonging the plasma and intratumoral concentrations of 5-FU, and offering protection to normal organs by increasing the endogenous uridine levels.


Other Notes

Homolog of thymidine


技术参数 Specifications
biological sourcesynthetic (organic)
Quality Level200
assay≥95% (HPLC)
formpowder
solubilitywater: 50 mg/mL, clear, colorless to yellow
storage temp.−20°C
SMILES stringCCC1=CN(C2CC(O)C(CO)O2)C(=O)NC1=O
InChI1S/C11H16N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h4,7-9,14-15H,2-3,5H2,1H3,(H,12,16,17)
InChI keyXACKNLSZYYIACO-UHFFFAOYSA-N
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