- 商品介绍
- 规格参数
- 包装参数
Application
4E1RCat was used to inhibit new protein synthesis in transformed primary chicken embryo fibroblasts.
Biochem/physiol Actions
4E1RCat ilnhibits the eIF4F translation initiation complex by binding to IF4E b and inhibiting the interaction between IF4E:eIF4G (IC50 = 3.2 μM). In in vitro translation experiments using MDA-MB-231 cells, 4E1RCat dose dependently inhibited cap-dependent translation, led to a decrease in polysome and 80S ribosomal subunits and reduced levels of the eIF4F-dependant proteins Mcl-1 and c-Myc.
4E1RCat is an inhibitor of translation initiation complex eIF4F
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the MAPKAPs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
| Quality Level | 100 |
| assay | ≥97% (HPLC) |
| form | powder |
| color | faint brown to dark brown-red |
| solubility | DMSO: ≥5 mg/mL |
| originator | Merck & Co., Inc., Kenilworth, NJ, U.S. |
| storage temp. | 2-8°C |
| SMILES string | OC(=O)c1ccc(cc1)N2C(=O)\C(=C\c3ccc(o3)-c4ccc(cc4)[N+]([O-])=O)C=C2c5ccccc5 |
| InChI | 1S/C28H18N2O6/c31-27-21(16-24-14-15-26(36-24)19-6-12-23(13-7-19)30(34)35)17-25(18-4-2-1-3-5-18)29(27)22-10-8-20(9-11-22)28(32)33/h1-17H,(H,32,33)/b21-16+ |
| InChI key | BBQRBOIMSKMFFO-LTGZKZEYSA-N |
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