Human MMP-1 ELISA Kit，1KIT，RAB0362-1KT，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

The Human MMP-1 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human MMP-1 cell lysate and tissue lysate.

Immunogen

Recombinant Human MMP1

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Matrix metalloproteinases (MMPs) enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular diseases, skeletal growth-plate disorders, and cancer metastasis. MMP-1 is a secreted collagenase with specificity toward Type I, II, III, VII, and X collagens, aggrecan, serpins, and α2-macroglobulin. It is overexpressed in lumbar intervertebral disc degeneration (IDD). It might also be associated with rheumatoid arthritis and osteoarthritis. MMP-1 is linked with juvenile idiopathic arthritis. Genetic variations in MMP-1 can affect the susceptibility and severity of this disease. MMP-1 might facilitate fibrous plaque disruption via degradation of interstitial collagens and thinning of the fibrous cap.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

技术参数 Specifications

species reactivity	human
packaging	kit of 96 wells (12 strips x 8 wells)
technique(s)	ELISA: suitable,capture ELISA: suitable
input	sample type tissue lysate sample type cell lysate
assay range	inter-assay cv: <12% intra-assay cv: <10% sensitivity: 8 pg/mL standard curve range: 24.69-18000 pg/mL
detection method	colorimetric
shipped in	wet ice
storage temp.	−20°C
Gene Information	human ... MMP1(4312)

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