- 商品介绍
- 规格参数
- 包装参数
Application
SR-12813 was used as control in pregnane X receptor (PXR) binding assay performed in HepG2 liver carcinoma cells and PXR-activation assay mediated by dehydroepiandrosterone in human hepatocytes.
Biochem/physiol Actions
SR 12813 is a pregnane X receptor (PXR, NR 112) agonist; cholesterol lowering drug; HMGCoA reductase inhibitor.
SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity. It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
| biological source | synthetic (organic) |
| Quality Level | 100 |
| assay | ≥98% |
| form | solid |
| solubility | DMSO: ≥10 mg/mL,H2O: insoluble |
| originator | GlaxoSmithKline |
| SMILES string | CCOP(=O)(OCC)C(=C/c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C)\P(=O)(OCC)OCC |
| InChI | 1S/C24H42O7P2/c1-11-28-32(26,29-12-2)21(33(27,30-13-3)31-14-4)17-18-15-19(23(5,6)7)22(25)20(16-18)24(8,9)10/h15-17,25H,11-14H2,1-10H3 |
| InChI key | YQLJDECYQDRSBI-UHFFFAOYSA-N |
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¥ 2814.26
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¥ 1779.22
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¥ 1509.00
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¥ 165230.53
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¥ 145427.01
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¥ 17652.29
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